[HTML][HTML] The role of collagen structure in mitogen stimulation of ERK, cyclin D1 expression, and G1-S progression in rat hepatocytes
JT Fassett, D Tobolt, CJ Nelsen, JH Albrecht… - Journal of Biological …, 2003 - ASBMB
Adhesion to type 1 collagen can elicit different cellular responses dependent upon whether
the collagen is in a fibrillar form (gel) or monomeric form (film). Hepatocytes adherent to
collagen film spread extensively, express cyclin D1, and increase DNA synthesis in
response to epidermal growth factor, whereas hepatocytes adherent to collagen gel have
increased differentiated function, but lower DNA synthesis. The signaling mechanisms by
which different forms of type I collagen modulate cell cycle progression are unknown. When …
the collagen is in a fibrillar form (gel) or monomeric form (film). Hepatocytes adherent to
collagen film spread extensively, express cyclin D1, and increase DNA synthesis in
response to epidermal growth factor, whereas hepatocytes adherent to collagen gel have
increased differentiated function, but lower DNA synthesis. The signaling mechanisms by
which different forms of type I collagen modulate cell cycle progression are unknown. When …