Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions
KE Foreman, J Friborg, B Chandran, H Katano… - Journal of …, 2001 - Elsevier
Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) has
been implicated in the development of Kaposi's sarcoma (KS) and several B-cell
lymphoproliferative diseases. Serologic and molecular genetic association data has
implicated HHV-8 as the causal agent of KS, but its role in the development of KS lesions is
not understood. To examine the etiology of KS, HHV-8 was injected into normal human skin
transplanted onto SCID mice. Injection of HHV-8 induced lesion formation that is …
been implicated in the development of Kaposi's sarcoma (KS) and several B-cell
lymphoproliferative diseases. Serologic and molecular genetic association data has
implicated HHV-8 as the causal agent of KS, but its role in the development of KS lesions is
not understood. To examine the etiology of KS, HHV-8 was injected into normal human skin
transplanted onto SCID mice. Injection of HHV-8 induced lesion formation that is …