The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft
GR Picchio, RE Sabbe, RJ Gulizia, M McGrath… - Virology, 1997 - Elsevier
GR Picchio, RE Sabbe, RJ Gulizia, M McGrath, BG Herndier, DE Mosier
Virology, 1997•ElsevierThe body-cavity-based lymphoma cell line BCBL-1, which is infected with Kaposi's sarcoma-
associated herpesvirus/human herpesvirus 8, was injected alone or with human peripheral
blood mononuclear cells into SCID mice. Immunoblastic lymphomas developed at or near
the site of injection. The lymphomas appeared to derive exclusively from the injected BCBL-
1 cells and not from the injected human PBMC. The tumors elicited a marked murine
angiogenic response, but known angiogenic cytokines were not detected in BCBL-1 cells …
associated herpesvirus/human herpesvirus 8, was injected alone or with human peripheral
blood mononuclear cells into SCID mice. Immunoblastic lymphomas developed at or near
the site of injection. The lymphomas appeared to derive exclusively from the injected BCBL-
1 cells and not from the injected human PBMC. The tumors elicited a marked murine
angiogenic response, but known angiogenic cytokines were not detected in BCBL-1 cells …
The body-cavity-based lymphoma cell line BCBL-1, which is infected with Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, was injected alone or with human peripheral blood mononuclear cells into SCID mice. Immunoblastic lymphomas developed at or near the site of injection. The lymphomas appeared to derive exclusively from the injected BCBL-1 cells and not from the injected human PBMC. The tumors elicited a marked murine angiogenic response, but known angiogenic cytokines were not detected in BCBL-1 cells. Transfer of BCBL-1 cells to SCID mice may represent anin vivomodel for the study of KSHV/HHV8-stimulated angiogenesis.
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