[HTML][HTML] The protein tyrosine kinase inhibitor SU5614 inhibits VEGF-induced endothelial cell sprouting and induces growth arrest and apoptosis by inhibition of c-kit in …
K Spiekermann, F Faber, R Voswinckel… - Experimental …, 2002 - Elsevier
OBJECTIVE: Angiogenesis, the process of new blood vessel formation, is a critical process
during growth and metastasis of solid tumors and might also represent a promising
therapeutical target in patients with acute myeloid leukemia (AML). METHODS: In this study,
we analyzed the expression of vascular endothelial growth factor receptors (VEGFR)-1/2
and its ligand VEGF in AML cell lines and characterized the inhibitory activity of the protein
tyrosine kinase (PTK) inhibitor SU5614 on human endothelial and leukemic cells …
during growth and metastasis of solid tumors and might also represent a promising
therapeutical target in patients with acute myeloid leukemia (AML). METHODS: In this study,
we analyzed the expression of vascular endothelial growth factor receptors (VEGFR)-1/2
and its ligand VEGF in AML cell lines and characterized the inhibitory activity of the protein
tyrosine kinase (PTK) inhibitor SU5614 on human endothelial and leukemic cells …