T-cell growth factors and the treatment of patients with cancer
MT Lotze - Clinical immunology and immunopathology, 1992 - Elsevier
T-cell maturation has traditionally been felt to occur primarily within the thymus but it is now
clear that dynamic processes in the periphery govern many functions such as T-cell
activation, proliferation, tolerization, and migration into peripheral tissues. Four T-cell growth
factors have now been identified. These include: interleukin-2 (IL-2), IL-4, IL-7, and a potent
cofactor recently described, IL-10. These factors are believed to work synergistically in the
fine regulation of the lymphoid pool. Both IL-2 and IL-4 have entered clinical trials with …
clear that dynamic processes in the periphery govern many functions such as T-cell
activation, proliferation, tolerization, and migration into peripheral tissues. Four T-cell growth
factors have now been identified. These include: interleukin-2 (IL-2), IL-4, IL-7, and a potent
cofactor recently described, IL-10. These factors are believed to work synergistically in the
fine regulation of the lymphoid pool. Both IL-2 and IL-4 have entered clinical trials with …