[HTML][HTML] Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts
JE Park, MC Lenter, RN Zimmermann… - Journal of Biological …, 1999 - ASBMB
Proteolytic degradation of extracellular matrix (ECM) components during tissue remodeling
plays a pivotal role in normal and pathological processes including wound healing,
inflammation, tumor invasion, and metastasis. Proteolytic enzymes in tumors may activate or
release growth factors from the ECM or act directly on the ECM itself, thereby facilitating
angiogenesis or tumor cell migration. Fibroblast activation protein (FAP) is a cell surface
antigen of reactive tumor stromal fibroblasts found in epithelial cancers and in granulation …
plays a pivotal role in normal and pathological processes including wound healing,
inflammation, tumor invasion, and metastasis. Proteolytic enzymes in tumors may activate or
release growth factors from the ECM or act directly on the ECM itself, thereby facilitating
angiogenesis or tumor cell migration. Fibroblast activation protein (FAP) is a cell surface
antigen of reactive tumor stromal fibroblasts found in epithelial cancers and in granulation …