Abnormal glomerular basement membrane laminins in murine, canine, and human Alport syndrome: aberrant laminin α2 deposition is species independent
CE Kashtan, Y Kim, GE Lees, PS Thorner… - Journal of the …, 2001 - journals.lww.com
Kidneys from mice, dogs, and humans with X-linked and autosomal-recessive forms of
Alport syndrome were examined by immunofluorescence for expression of laminin α, β, and
γ chains using monospecific antibodies. Laminin α2 chain was absent from glomerular
basement membranes (GBM) in normal human, murine, and canine kidneys but was
abnormally deposited in Alport GBM, regardless of species or inheritance pattern. In murine
and canine Alport kidneys, laminin α2 seems to be deposited as part of both laminin-2 …
Alport syndrome were examined by immunofluorescence for expression of laminin α, β, and
γ chains using monospecific antibodies. Laminin α2 chain was absent from glomerular
basement membranes (GBM) in normal human, murine, and canine kidneys but was
abnormally deposited in Alport GBM, regardless of species or inheritance pattern. In murine
and canine Alport kidneys, laminin α2 seems to be deposited as part of both laminin-2 …