[HTML][HTML] Distinct roles for Src tyrosine kinase in β2-adrenergic receptor signaling to MAPK and in receptor internalization
J Huang, Y Sun, XY Huang - Journal of Biological Chemistry, 2004 - ASBMB
G protein-coupled receptors form the largest family of membrane receptors and transmit
diverse ligand signals to modulate various cellular responses. After activation by their
ligands, some of these G protein-coupled receptors are desensitized, internalized
(endocytosed), and down-regulated (degraded). In HEK 293 cells, the G s-coupled β 2-
adrenergic receptor was postulated to initiate a second wave of signaling, such as the
activation of the mitogen-activated protein kinase (MAPK) pathway after the receptor is …
diverse ligand signals to modulate various cellular responses. After activation by their
ligands, some of these G protein-coupled receptors are desensitized, internalized
(endocytosed), and down-regulated (degraded). In HEK 293 cells, the G s-coupled β 2-
adrenergic receptor was postulated to initiate a second wave of signaling, such as the
activation of the mitogen-activated protein kinase (MAPK) pathway after the receptor is …