[HTML][HTML] Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells

AJ Ratner, R Bryan, A Weber, S Nguyen… - Journal of Biological …, 2001 - ASBMB
Much of the pulmonary disease in cystic fibrosis is associated with polymorphonuclear
leukocyte-dominated airway inflammation caused by bacterial infection. Respiratory
epithelial cells express the polymorphonuclear chemokine interleukin-8 (IL-8) in response to
ligation of asialylated glycolipid receptors, which are increased on damaged or regenerating
cells and those with cystic fibrosis transmembrane conductance regulator mutations.
Because both Pseudomonas aeruginosa andStaphylococcus aureus, the most common …