Conserved sequences in bacterial and viral sialidases
P Roggentin, B Rothe, JB Kaper, J Galen… - Glycoconjugate …, 1989 - Springer
P Roggentin, B Rothe, JB Kaper, J Galen, L Lawrisuk, ER Vimr, R Schauer
Glycoconjugate journal, 1989•SpringerThe genes of the bacterial sialidases from Clostridium sordellii G12, C. perfringens A99,
Salmonella typhimurium LT-2 and Vibrio cholerae 395 sequenced so far were examined for
homologies and were compared with sequences of viral sialidases. Each of the bacterial
sialidases contains a short sequence of twelve amino-acids, which is repeated at four
positions in the protein. All these sequences exhibit significant similarities. Comparing the
repeated sequences of the four sialidases, five amino-acids were found to be highly …
Salmonella typhimurium LT-2 and Vibrio cholerae 395 sequenced so far were examined for
homologies and were compared with sequences of viral sialidases. Each of the bacterial
sialidases contains a short sequence of twelve amino-acids, which is repeated at four
positions in the protein. All these sequences exhibit significant similarities. Comparing the
repeated sequences of the four sialidases, five amino-acids were found to be highly …
Abstract
The genes of the bacterial sialidases fromClostridium sordellii G12,C. perfringens A99,Salmonella typhimurium LT-2 andVibrio cholerae 395 sequenced so far were examined for homologies and were compared with sequences of viral sialidases.
Each of the bacterial sialidases contains a short sequence of twelve amino-acids, which is repeated at four positions in the protein. All these sequences exhibit significant similarities. Comparing the repeated sequences of the four sialidases, five amino-acids were found to be highly conserved at defined positions: Ser-X-Asp-X-Gly-X-Thr-Trp. Additionally, most of the distances betweeen the four repeated regions are also conserved among the different sialidases. The conserved bacterial sequences show similarity with sialidases of influenza A H7N1 and H13N9.
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