The cytokine network in psoriasis

BJ Nickoloff - Archives of dermatology, 1991 - jamanetwork.com
After more than a century of benign neglect, the epidermal keratinocyte is finally being
recognized for its potential to initiate and propagate inflammatory/immunological skin
diseases. In psoriasis, the keratinocyte, on activation, actively participates in a multicellular,
multimolecular network coordinated by cytokines. This new appreciation and recognition of
the central importance of epidermal keratinocytes, with its distinctive immunobiological
capabilities apart from surrounding non-epithelial cell types, has occurred by using …