In vivo and in vitro Suppression of Humoral and Cellular Immunological Response by Rifampicin
E Pǎunescu - Nature, 1970 - nature.com
E Pǎunescu
Nature, 1970•nature.comAbstract RIFAMPICIN—3-(4-methyl-l-piperazyl-iminomethyl)-rifamycin SV—a semi-synthetic
derivative of rifamycin which was isolated from Streptomyces mediterraneus 1, is a clinically
useful, orally active antibiotic. Even at low concentrations (0.5–5 µg/ml.), it is known to inhibit
microbial growth by blocking cellular DNA-directed RNA polymerase (EC 2.7. 7.6) 2, 3.
Although similar inhibition of RNA synthesis does not occur in mammalian cell-free systems
unless large amounts of rifampicin (200 µg/ml.) are used4, concentrations exceeding 10 µg …
derivative of rifamycin which was isolated from Streptomyces mediterraneus 1, is a clinically
useful, orally active antibiotic. Even at low concentrations (0.5–5 µg/ml.), it is known to inhibit
microbial growth by blocking cellular DNA-directed RNA polymerase (EC 2.7. 7.6) 2, 3.
Although similar inhibition of RNA synthesis does not occur in mammalian cell-free systems
unless large amounts of rifampicin (200 µg/ml.) are used4, concentrations exceeding 10 µg …
Abstract
RIFAMPICIN—3 - (4 - methyl - l -piperazyl - iminomethyl) -rifamycin SV—a semi-synthetic derivative of rifamycin which was isolated from Streptomyces mediterraneus1, is a clinically useful, orally active antibiotic. Even at low concentrations (0.5–5 µg/ml.), it is known to inhibit microbial growth by blocking cellular DNA-directed RNA polymerase (EC 2.7.7.6)2,3. Although similar inhibition of RNA synthesis does not occur in mammalian cell-free systems unless large amounts of rifampicin (200 µg/ml.) are used4, concentrations exceeding 10 µg of rifampicin/ml. medium cause detectable damage in the case of monolayer cultures of BHK21 C 13 cells5.
nature.com