[HTML][HTML] Autoregulatory role of endothelium-derived nitric oxide (NO) on lipopolysaccharide-induced vascular inducible NO synthase expression and function
PA Vo, B Lad, JAP Tomlinson, S Francis… - Journal of Biological …, 2005 - ASBMB
Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) is responsible for
sepsis-induced hypotension and plays a major contributory role in the ensuing multiorgan
failure. The present study aimed to elucidate the role of endothelial NO in
lipopolysaccharide (LPS)-induced iNOS expression, in isolated rat aortic rings. Exposure to
LPS (1 μg/ml, 5 h) resulted in a reversal of phenylephrine precontracted tone in aortic rings
(70.7±3.2%). This relaxation was associated with iNOS expression and NF-κB activation …
sepsis-induced hypotension and plays a major contributory role in the ensuing multiorgan
failure. The present study aimed to elucidate the role of endothelial NO in
lipopolysaccharide (LPS)-induced iNOS expression, in isolated rat aortic rings. Exposure to
LPS (1 μg/ml, 5 h) resulted in a reversal of phenylephrine precontracted tone in aortic rings
(70.7±3.2%). This relaxation was associated with iNOS expression and NF-κB activation …