[HTML][HTML] Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-α expression
RA McKay, LJ Miraglia, LL Cummins, SR Owens… - Journal of Biological …, 1999 - ASBMB
The use of antisense oligonucleotides to inhibit the expression of targeted mRNA
sequences is becoming increasingly commonplace. Although effective, the most widely
used oligonucleotide modification (phosphorothioate) has some limitations. In previous
studies we have described a 20-mer phosphorothioate oligodeoxynucleotide inhibitor of
human protein kinase C-α expression. In an effort to identify improved antisense inhibitors of
protein kinase C expression, a series of 2′ modifications have been incorporated into the …
sequences is becoming increasingly commonplace. Although effective, the most widely
used oligonucleotide modification (phosphorothioate) has some limitations. In previous
studies we have described a 20-mer phosphorothioate oligodeoxynucleotide inhibitor of
human protein kinase C-α expression. In an effort to identify improved antisense inhibitors of
protein kinase C expression, a series of 2′ modifications have been incorporated into the …