Direct effects of Th2 cytokines on airway smooth muscle
SA Shore - Current opinion in pharmacology, 2004 - Elsevier
Data summarized in this review indicate that airway smooth muscle cells express receptors
for cytokines derived from CD4+ T cells and that these cytokines, particularly interleukin-13,
can act directly on airway smooth muscle cells leading to changes in contractile and relaxant
responses, proliferation, and the ability of smooth muscle cells to generate chemokines such
as eotaxin and TARC. Moreover, the interleukin-4 receptor-α genotype of airway smooth
muscle appears to be an important determinant of its response to Th2 cytokines …
for cytokines derived from CD4+ T cells and that these cytokines, particularly interleukin-13,
can act directly on airway smooth muscle cells leading to changes in contractile and relaxant
responses, proliferation, and the ability of smooth muscle cells to generate chemokines such
as eotaxin and TARC. Moreover, the interleukin-4 receptor-α genotype of airway smooth
muscle appears to be an important determinant of its response to Th2 cytokines …