Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene
C Hubert, AM Houot, P Corvol, F Soubrier - Journal of biological chemistry, 1991 - ASBMB
Overlapping genomic clones containing the entire sequence of the human angiotensin I-
converting enzyme (ACE) gene were isolated from a lamda phage human DNA library. This
gene spans 21 kilobases (kb) and comprises 26 exons, ranging in size from 88 to 481 base
pairs. Intron-exon boundaries were sequenced and the relative positions of the exons were
mapped. The two different mRNAs transcribed from the ACE gene were assigned to their
respective exons. The large endothelial type ACE mRNA (4.3 kb long) is transcribed from …
converting enzyme (ACE) gene were isolated from a lamda phage human DNA library. This
gene spans 21 kilobases (kb) and comprises 26 exons, ranging in size from 88 to 481 base
pairs. Intron-exon boundaries were sequenced and the relative positions of the exons were
mapped. The two different mRNAs transcribed from the ACE gene were assigned to their
respective exons. The large endothelial type ACE mRNA (4.3 kb long) is transcribed from …