Lifespan of human lymphocyte subsets defined by CD45 isoforms
CA Michie, A McLean, C Alcock, PCL Beverley - Nature, 1992 - nature.com
CA Michie, A McLean, C Alcock, PCL Beverley
Nature, 1992•nature.comTHE lifespan of thymic-derived or T lymphocytes is of particular interest because of their
central role in immunological memory. Is the recall of a vaccination or early infection, which
may be demonstrated clinically up to 50 years after antigen exposure1, retained by a long-
lived cell, or by its progeny? Using the observation that T lymphocyte expression of isoforms
of CD45 corresponds with their ability to respond to recall antigens, we have investigated
the lifespan of both CD45RO (the subset containing responders, or'memory'cells) and …
central role in immunological memory. Is the recall of a vaccination or early infection, which
may be demonstrated clinically up to 50 years after antigen exposure1, retained by a long-
lived cell, or by its progeny? Using the observation that T lymphocyte expression of isoforms
of CD45 corresponds with their ability to respond to recall antigens, we have investigated
the lifespan of both CD45RO (the subset containing responders, or'memory'cells) and …
Abstract
THE lifespan of thymic-derived or T lymphocytes is of particular interest because of their central role in immunological memory. Is the recall of a vaccination or early infection, which may be demonstrated clinically up to 50 years after antigen exposure1, retained by a long-lived cell, or by its progeny? Using the observation that T lymphocyte expression of isoforms of CD45 corresponds with their ability to respond to recall antigens, we have investigated the lifespan of both CD45RO (the subset containing responders, or 'memory' cells) and CD45RA (the unresponsive, or 'naive' subset) lymphocytes in a group of patients after radiotherapy. Here we report rapid loss of unstable chromosomes from the CD45RO but not the CD45RA pool. Immunological memory therefore apparently resides in a population with a more rapid rate of division. Differing survival curves for the two subsets are best described by a model in which there is also reversion in vivo from the CD45RO to the CD45RA phenotype. Expression of CD45RO in T cells may therefore be reversible.
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