Dysfunction of soluble guanylyl cyclase in aorta and kidney of Goto–Kakizaki rats: influence of age and diabetic state
K Witte, K Jacke, R Stahrenberg, G Arlt, I Reitenbach… - Nitric oxide, 2002 - Elsevier
Type 2 diabetes mellitus is frequently associated with arterial hypertension. The
mechanisms involved in this association are not known in detail, but endothelial dysfunction
and a blunted vascular response to endogenous vasodilators are thought to play a role. In
the present study we investigated the in vitro activity of vascular and renal soluble guanylyl
cyclase in type 2 diabetic Goto–Kakizaki rats aged 5, 15, and 30 weeks, in comparison with
age-matched Wistar controls. Blood pressure was monitored by radiotelemetry, and serum …
mechanisms involved in this association are not known in detail, but endothelial dysfunction
and a blunted vascular response to endogenous vasodilators are thought to play a role. In
the present study we investigated the in vitro activity of vascular and renal soluble guanylyl
cyclase in type 2 diabetic Goto–Kakizaki rats aged 5, 15, and 30 weeks, in comparison with
age-matched Wistar controls. Blood pressure was monitored by radiotelemetry, and serum …