Frequency and nature of cytokine gene polymorphisms in type 1 autoimmune hepatitis
S Cookson, PK Constantini, M Clare, JA Underhill… - Hepatology, 1999 - journals.lww.com
Genetic involvement in type 1 autoimmune hepatitis (AIH) is indicated by a marked female
preponderance and strong, well-established, human leukocyte antigen (HLA) associations.
These associations, however, are not universal and a number of genes outside the major
histocompatibility complex may also play a role in susceptibility to type 1 AIH. Prime
candidates at present are those polymorphic genes encoding the proinflammatory and
immunoregulatory cytokines. The aim of this study was to investigate, for the first time, 2 …
preponderance and strong, well-established, human leukocyte antigen (HLA) associations.
These associations, however, are not universal and a number of genes outside the major
histocompatibility complex may also play a role in susceptibility to type 1 AIH. Prime
candidates at present are those polymorphic genes encoding the proinflammatory and
immunoregulatory cytokines. The aim of this study was to investigate, for the first time, 2 …