B-Cell activity in weanling Lewis rats was inhibited by injections of goat anti-rat mu-chain
antiserum (GAMS) from birth on, as demonstrated by markedly reduced or absent myelin
basic protein (MBP) binding activity of sera. Following challenge with guinea pig spinal cord
(GPSC)-complete Freund's adjuvant (CFA) and continued GAMS treatment, all rats
remained clinically well without a trace of neurological signs. Histopathologically, central
nervous system (CNS) perivascular fibrin deposits, typically accompanying paralytic signs of …