Publisher Summary This chapter discusses the immune response to chemically induced,
transplantable tumors in syngeneic mice. It deals with those tumors that are immunogenic by
virtue of their possession of tumor-specific, transplantation rejection antigens. A framework
of evidence has been presented in the chapter that supports the hypothesis of down-
regulation of antitumor immune response. Direct evidence for the hypothesis consists of the
finding that infusion of suppressor spleen cells from donors with a large tumor can prevent …