Changes within the thyroid axis during critical illness
RP Peeters, Y Debaveye, E Fliers… - Critical Care …, 2006 - criticalcare.theclinics.com
Thyroid hormone is essential for the regulation of energy metabolism, and for the
physiological function of virtually all tissues [1, 2]. The production of thyroxine (T4) by the
thyroid gland is regulated by the classic hypothalamuspituitary-thyroid axis, in which the
anterior pituitary releases thyroid stimulating hormone (TSH) thyrotropin as a result of the
stimulation of hypothalamic thyrotropin-releasing hormone (TRH) from the paraventricular
nucleus [1–5]. The biological activity of thyroid hormone (ie, the availability of the active …
physiological function of virtually all tissues [1, 2]. The production of thyroxine (T4) by the
thyroid gland is regulated by the classic hypothalamuspituitary-thyroid axis, in which the
anterior pituitary releases thyroid stimulating hormone (TSH) thyrotropin as a result of the
stimulation of hypothalamic thyrotropin-releasing hormone (TRH) from the paraventricular
nucleus [1–5]. The biological activity of thyroid hormone (ie, the availability of the active …