In the hematopoietic system, lineage commitment and differentiation is controlled by the
combinatorial action of transcription factors from diverse families. SCL is a basic helix-loop-
helix transcription factor that is an essential regulator at several levels in the hematopoietic
hierarchy and whose inappropriate regulation frequently contributes to the development of
pediatric T-cell acute lymphoblastic leukemia. This review discusses advances that have
shed important light on the functions played by SCL during normal hematopoiesis and …