Entry of Trypanosoma brucei gambiense into microvascular endothelial cells of the human blood–brain barrier
OV Nikolskaia, YV Kim, O Kovbasnjuk, KJ Kim… - International journal for …, 2006 - Elsevier
Using an in vitro model of the human blood–brain barrier consisting of human brain
microvascular endothelial cells we recently demonstrated that Trypanosoma brucei
gambiense bloodstream-forms efficiently cross these cells via a paracellular route while
Trypanosoma brucei brucei crosses these cells poorly. Using a combination of techniques
that include fluorescence activated cell sorting, confocal and electron microscopy, we now
show that some Tb gambiense blood stream form parasites have the capacity to enter …
microvascular endothelial cells we recently demonstrated that Trypanosoma brucei
gambiense bloodstream-forms efficiently cross these cells via a paracellular route while
Trypanosoma brucei brucei crosses these cells poorly. Using a combination of techniques
that include fluorescence activated cell sorting, confocal and electron microscopy, we now
show that some Tb gambiense blood stream form parasites have the capacity to enter …