[HTML][HTML] A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor
C Levy, H Nechushtan, E Razin - Journal of Biological Chemistry, 2002 - ASBMB
In vitro and in vivoevidence suggest that microphthalmia transcription factor (MITF) plays a
key regulatory role in tissue-specific gene regulation in several cell types, including
melanocytes, osteoclasts, and mast cells. A yeast two-hybrid search, using a portion of a
nonmutated MITF gene as the bait in the screening of a mast cell library, resulted in the
isolation of the STAT3 inhibitor, PIAS3. PIAS3 is a transcriptional inhibitor that acts by
specifically inhibiting STAT3's DNA binding activity. We found that it can directly associate …
key regulatory role in tissue-specific gene regulation in several cell types, including
melanocytes, osteoclasts, and mast cells. A yeast two-hybrid search, using a portion of a
nonmutated MITF gene as the bait in the screening of a mast cell library, resulted in the
isolation of the STAT3 inhibitor, PIAS3. PIAS3 is a transcriptional inhibitor that acts by
specifically inhibiting STAT3's DNA binding activity. We found that it can directly associate …