[HTML][HTML] Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages
Cyclooxygenase-2 (COX-2), the enzyme primarily responsible for induced prostaglandin
synthesis, is an immediate early gene induced by endotoxin in macrophages. We
investigated the cis-acting elements of the COX-2 5′-flanking sequence, the transcription
factors and signaling pathways responsible for transcriptional activation of the COX-2 gene
in endotoxin-treated murine RAW 264.7 macrophages. Luciferase reporter constructs with
alterations in presumptive cis-acting transcriptional regulatory elements demonstrate that the …
synthesis, is an immediate early gene induced by endotoxin in macrophages. We
investigated the cis-acting elements of the COX-2 5′-flanking sequence, the transcription
factors and signaling pathways responsible for transcriptional activation of the COX-2 gene
in endotoxin-treated murine RAW 264.7 macrophages. Luciferase reporter constructs with
alterations in presumptive cis-acting transcriptional regulatory elements demonstrate that the …