[HTML][HTML] Transcriptional regulation of the cyclooxygenase-2 gene in activated mast cells
ST Reddy, DJ Wadleigh, HR Herschman - Journal of Biological Chemistry, 2000 - ASBMB
Activation of mast cells by aggregation of their IgE receptors induces rapid and transient
synthesis of cyclooxygenase-2 (COX-2). In this study we investigated (i) the cis-acting
response elements and transcription factors active at the COX-2 promoter and (ii) the signal
transduction pathways mediating COX-2 induction following aggregation of mast cell IgE
receptors. Transient transfection assays with COX-2 promoter/luciferase constructs suggest
that a consensus cyclic AMP response element is essential for induced COX-2 expression …
synthesis of cyclooxygenase-2 (COX-2). In this study we investigated (i) the cis-acting
response elements and transcription factors active at the COX-2 promoter and (ii) the signal
transduction pathways mediating COX-2 induction following aggregation of mast cell IgE
receptors. Transient transfection assays with COX-2 promoter/luciferase constructs suggest
that a consensus cyclic AMP response element is essential for induced COX-2 expression …