Delivery of bioactive molecules into the cell: the Trojan horse approach

GPH Dietz, M Bähr - Molecular and Cellular Neuroscience, 2004 - Elsevier
In recent years, vast amounts of data on the mechanisms of neural de-and regeneration
have accumulated. However, only in disproportionally few cases has this led to efficient
therapies for human patients. Part of the problem is to deliver cell death-averting genes or
gene products across the blood–brain barrier (BBB) and cellular membranes. The discovery
of Antennapedia (Antp)-mediated transduction of heterologous proteins into cells in 1992
and other “Trojan horse peptides” raised hopes that often-frustrating attempts to deliver …