We performed an immunohistochemical study to try to determine the cellular source of
interleukin-8 (IL-8) in psoriatic skin lesions. IL-8 was positively stained in the vast majority of
neutrophils but not in the mononuclear cells, macrophages, or keratinocytes. IL-8-positive
neutrophils were seen both in Munro's microabcesses in cases of psoriasis vulgaris and in a
small spongiform pustule and much larger macropustules of Kogoj in cases of pustular
psoriasis. Some IL-8-positive neutrophils were observed in the upper dermis of pustular …