Role of IL-5 during primary and secondary immune response to acetylcholine receptor
MA Poussin, E Goluszko, JU Franco… - Journal of …, 2002 - Elsevier
To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune
myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5
gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly
reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5
KO mice displayed intact secondary antibody and lymphoproliferative responses to
acetylcholine receptor (AChR) after immunization with this molecule. However, the relative …
myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5
gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly
reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5
KO mice displayed intact secondary antibody and lymphoproliferative responses to
acetylcholine receptor (AChR) after immunization with this molecule. However, the relative …