The role of major histocompatibility complex genes in myasthenia gravis and experimental autoimmune myasthenia gravis pathogenesis
R Kaul, M Shenoy, P Christadoss - Advances in neuroimmunology, 1994 - Elsevier
The major histocompatibility complex (MHC) molecules play a crucial role in the selection of
the T cell repertoire and in initiating immune responses by presenting antigen to CD4+ and
CD8+ T cells. The positively selected CD4+ and CDS+ T cells in the context of MHC class II
and class I, respectively, constitute the immunocompetent T cell repertoire, while the
negative selection (deletion of self reactive T cells) forms a basis for immunological
tolerance. Specific MHC class II sequences have been linked with the development of …
the T cell repertoire and in initiating immune responses by presenting antigen to CD4+ and
CD8+ T cells. The positively selected CD4+ and CDS+ T cells in the context of MHC class II
and class I, respectively, constitute the immunocompetent T cell repertoire, while the
negative selection (deletion of self reactive T cells) forms a basis for immunological
tolerance. Specific MHC class II sequences have been linked with the development of …