T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis

ZY Wang, B Diethelm-Okita, DK Okita… - Journal of …, 2000 - Elsevier
We examined the proliferative response of blood CD4+ cells to muscle acetylcholine
receptor (AChR) subunits and the epitope repertoire of the ε and γ subunits, in ocular
myasthenia gravis (oMG) patients and healthy subjects. oMG patients seldom recognized all
subunits. The frequency and intensity of recognition was the same for all subunits,
irrespective of the disease duration. The responses in oMG were lower than in generalized
myasthenia gravis. Healthy subjects had frequent, low responses to one or more subunits …