Antigen processing by the proteasome
PM Kloetzel - Nature reviews Molecular cell biology, 2001 - nature.com
PM Kloetzel
Nature reviews Molecular cell biology, 2001•nature.comThe proteasome is an essential part of our immune surveillance mechanisms: by generating
peptides from intracellular antigens it provides peptides that are then'presented'to T cells.
But proteasomes? the waste-disposal units of the cell? typically do not generate peptides for
antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the
immune system well?
peptides from intracellular antigens it provides peptides that are then'presented'to T cells.
But proteasomes? the waste-disposal units of the cell? typically do not generate peptides for
antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the
immune system well?
Abstract
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes ? the waste-disposal units of the cell ? typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?
nature.com