[HTML][HTML] Impaired kit-but not FcεRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85α gene products
JM Lu-Kuo, DA Fruman, DM Joyal, LC Cantley… - Journal of Biological …, 2000 - ASBMB
The class IA phosphoinositide 3-kinases (PI3Ks) consist of a 110-kDa catalytic domain and
a regulatory subunit encoded by the p85α, p85β, or p55γ genes. We have determined the
effects of disrupting the p85α gene on the responses of mast cells stimulated by the cross-
linking of Kit and FcεRI, receptors that reflect innate and adaptive responses, respectively.
The absence of p85α gene products partially inhibited Kit ligand/stem cell factor-induced
secretory granule exocytosis, proliferation, and phosphorylation of the serine/threonine …
a regulatory subunit encoded by the p85α, p85β, or p55γ genes. We have determined the
effects of disrupting the p85α gene on the responses of mast cells stimulated by the cross-
linking of Kit and FcεRI, receptors that reflect innate and adaptive responses, respectively.
The absence of p85α gene products partially inhibited Kit ligand/stem cell factor-induced
secretory granule exocytosis, proliferation, and phosphorylation of the serine/threonine …