Many proinflammatory cytokines and hormones have been demonstrated to be involved in
insulin resistance. However, the molecular mechanisms whereby these cytokines and
hormones inhibit insulin signaling are not completely understood. We observed that several
cytokines and hormones that induce insulin resistance also stimulate SOCS3 expression in
3T3-L1 adipocytes and that SOCS3 mRNA is increased in adipose tissue of obese/diabetic
mice. We then hypothesized that SOCS3 may mediate cytokine-and hormone-induced …