A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

KS Makarova, L Aravind, EV Koonin - Trends in biochemical sciences, 2000 - cell.com
Trends in biochemical sciences, 2000cell.com
51 x, any residue; alternative residues are in brackets]. This pattern retrieved 27 sequences
from the NR database that comprise the bulk of the new superfamily (including the
sequences from Chlamydia, C. elegans and LFV), together with the arterivirus proteases; no
false positives were retrieved in this search. The catalytic cysteine is replaced by a serine in
the OTU sequence (Fig. 1). It is unclear whether OTU is likely to be an active protease, with
the serine in motif I functioning as a nucleophile instead of a cysteine, or an inactivated …
51 x, any residue; alternative residues are in brackets]. This pattern retrieved 27 sequences from the NR database that comprise the bulk of the new superfamily (including the sequences from Chlamydia, C. elegans and LFV), together with the arterivirus proteases; no false positives were retrieved in this search.
The catalytic cysteine is replaced by a serine in the OTU sequence (Fig. 1). It is unclear whether OTU is likely to be an active protease, with the serine in motif I functioning as a nucleophile instead of a cysteine, or an inactivated protease homolog. Similarly, two Expressed Sequence Tag (EST) products from
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