[HTML][HTML] Negative regulation of JNK signaling by the tumor suppressor CYLD
W Reiley, M Zhang, SC Sun - Journal of Biological Chemistry, 2004 - ASBMB
CYLD is a tumor suppressor that is mutated in familial cylindromatosis, an autosomal
dominant predisposition to multiple tumors of the skin appendages. Recent studies suggest
that transfected CYLD has deubiquitinating enzyme activity and inhibits the activation of
transcription factor NF-κB. However, the role of endogenous CYLD in regulating cell
signaling remains poorly defined. Here we report a critical role for CYLD in negatively
regulating the c-Jun NH 2-terminal kinase (JNK). CYLD knockdown by RNA interference …
dominant predisposition to multiple tumors of the skin appendages. Recent studies suggest
that transfected CYLD has deubiquitinating enzyme activity and inhibits the activation of
transcription factor NF-κB. However, the role of endogenous CYLD in regulating cell
signaling remains poorly defined. Here we report a critical role for CYLD in negatively
regulating the c-Jun NH 2-terminal kinase (JNK). CYLD knockdown by RNA interference …