IGF-1, inflammation and stem cells: interactions during muscle regeneration

F Mourkioti, N Rosenthal - Trends in immunology, 2005 - cell.com
F Mourkioti, N Rosenthal
Trends in immunology, 2005cell.com
Insulin-like growth factor-I (IGF-1) is an important mediator in numerous developmental
processes, such as proliferation, differentiation, survival, growth, apoptosis and
regeneration. Mouse genetics have provided important insights into the signalling
mechanisms that are necessary for the coordination of muscle repair. Recent studies on the
role of IGF-1 in the promotion of cell recruitment to the injured muscle and the subsequent
resolution of the inflammatory response have unveiled new perspectives into local repair …
Insulin-like growth factor-I (IGF-1) is an important mediator in numerous developmental processes, such as proliferation, differentiation, survival, growth, apoptosis and regeneration. Mouse genetics have provided important insights into the signalling mechanisms that are necessary for the coordination of muscle repair. Recent studies on the role of IGF-1 in the promotion of cell recruitment to the injured muscle and the subsequent resolution of the inflammatory response have unveiled new perspectives into local repair mechanisms.
cell.com