[HTML][HTML] Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression
AD Choudhury, H Xu, R Baer - Journal of Biological Chemistry, 2004 - ASBMB
The BRCA1 tumor suppressor and the BARD1 protein form a stable heterodimeric complex
that can catalyze the formation of polyubiquitin chains. Expression of BRCA1 fluctuates in a
cell cycle-dependent manner, such that low steady-state levels of BRCA1 gene products are
found in resting cells and early G 1 cycling cells and high levels in S and G 2 phase cells.
Although transcriptional activation of the BRCA1 gene can account for induction of BRCA1
expression at the G 1/S transition, the mechanisms by which BRCA1 is down-regulated …
that can catalyze the formation of polyubiquitin chains. Expression of BRCA1 fluctuates in a
cell cycle-dependent manner, such that low steady-state levels of BRCA1 gene products are
found in resting cells and early G 1 cycling cells and high levels in S and G 2 phase cells.
Although transcriptional activation of the BRCA1 gene can account for induction of BRCA1
expression at the G 1/S transition, the mechanisms by which BRCA1 is down-regulated …