[HTML][HTML] Pituitary tumor transforming gene causes aneuploidy and p53-dependent and p53-independent apoptosis
R Yu, AP Heaney, W Lu, J Chen, S Melmed - Journal of Biological …, 2000 - ASBMB
The pituitary tumor transforming gene, PTTG, is abundantly expressed in several
neoplasms. We recently showed that PTTG overexpression is associated with apoptosis and
therefore have now studied the role of p53 in this process. In MCF-7 breast cancer cells that
express wild type p53, PTTG overexpression caused apoptosis. p53 was translocated to the
nuclei in cells expressing PTTG. Overexpression of p53, along with PTTG, augmented
apoptosis, whereas expression of the human papillomavirus E6 protein inhibited PTTG …
neoplasms. We recently showed that PTTG overexpression is associated with apoptosis and
therefore have now studied the role of p53 in this process. In MCF-7 breast cancer cells that
express wild type p53, PTTG overexpression caused apoptosis. p53 was translocated to the
nuclei in cells expressing PTTG. Overexpression of p53, along with PTTG, augmented
apoptosis, whereas expression of the human papillomavirus E6 protein inhibited PTTG …