Further aspects of muscular dystrophy in mdx mice
C Pastoret, A Sebille - Neuromuscular Disorders, 1993 - Elsevier
The histopathological aspects of leg muscles in young, adult and old mdx mice were
compared. Before 1 yr of age, the mutant showed a vigorous regeneration, following the
fibre necrosis, which led to hypertrophic muscles. Hypertrophy resulted from a mixture of
hypertrophic and small fibres but not from fibrosis. From the age of 15 months, the muscles
progressively atrophied and the fibres were atrophic or split. An important degree of fibrosis
occurred particularly in soleus and plantaris muscles. These aspects in old mdx mice are …
compared. Before 1 yr of age, the mutant showed a vigorous regeneration, following the
fibre necrosis, which led to hypertrophic muscles. Hypertrophy resulted from a mixture of
hypertrophic and small fibres but not from fibrosis. From the age of 15 months, the muscles
progressively atrophied and the fibres were atrophic or split. An important degree of fibrosis
occurred particularly in soleus and plantaris muscles. These aspects in old mdx mice are …