[HTML][HTML] Identification of peptide and protein ligands for the caveolin-scaffolding domain: implications for the interaction of caveolin with caveolae-associated proteins
Caveolin, a 21-24-kDa integral membrane protein, is a principal component of caveolae
membranes. We have suggested that caveolin functions as a scaffolding protein to organize
and concentrate certain caveolin-interacting proteins within caveolae membranes. In this
regard, caveolin co-purifies with a variety of lipid-modified signaling molecules, including G-
proteins, Src-like kinases, Ha-Ras, and eNOS. Using several independent approaches, it
has been shown that a 20-amino acid membrane proximal region of the cytosolic amino …
membranes. We have suggested that caveolin functions as a scaffolding protein to organize
and concentrate certain caveolin-interacting proteins within caveolae membranes. In this
regard, caveolin co-purifies with a variety of lipid-modified signaling molecules, including G-
proteins, Src-like kinases, Ha-Ras, and eNOS. Using several independent approaches, it
has been shown that a 20-amino acid membrane proximal region of the cytosolic amino …