[HTML][HTML] Caveolin-1 regulates transforming growth factor (TGF)-β/SMAD signaling through an interaction with the TGF-β type I receptor
Transforming growth factor-β (TGF-β) signaling proceeds from the cell membrane to the
nucleus through the cooperation of the type I and II serine/threonine kinase receptors and
their downstream SMAD effectors. Although various regulatory proteins affecting TGF-β-
mediated events have been described, relatively little is known about receptor interactions at
the level of the plasma membrane. Caveolae are cholesterol-rich membrane microdomains
that, along with their marker protein caveolin-1 (Cav-1), have been implicated in the …
nucleus through the cooperation of the type I and II serine/threonine kinase receptors and
their downstream SMAD effectors. Although various regulatory proteins affecting TGF-β-
mediated events have been described, relatively little is known about receptor interactions at
the level of the plasma membrane. Caveolae are cholesterol-rich membrane microdomains
that, along with their marker protein caveolin-1 (Cav-1), have been implicated in the …