Apocynin is an effective and selective inhibitor of the neutrophil oxidative burst in vitro. Other
neutrophil functions, tested in vitro, such as chemotaxis, exocytosis, phagocytosis and
intracellular killing of bacteria are unaffected by apocynin. These properties make apocynin
a potential anti-inflammatory agent in vivo. This was tested in WAG/Rij rats, injected
intracutaneously with tubercle bacteria in oil (complete Freund's adjuvant). We show here
that continuous administration of apocynin via the drinking water prevents the formation of …