Elastase activity in capillary and aortic endothelial cells.
DC West, S Kumar - Anticancer Research, 1986 - europepmc.org
DC West, S Kumar
Anticancer Research, 1986•europepmc.orgTissue cultured bovine capillary and aortic endothelial cells were examined for cellular and
secreted proteinase activity. Cell-lysates from both sources showed significant elastase
activity but differed in the level of activity and the pH-optimum and inhibition profile.
Secretion of elastase was only detected using aortic cells. Tumour angiogenesis factor
(TAF), heparin or 12-0-tetradecanoyl-phorbol-acetate (TPA) had no effect on the levels of
cell-associated or secreted elastase.
secreted proteinase activity. Cell-lysates from both sources showed significant elastase
activity but differed in the level of activity and the pH-optimum and inhibition profile.
Secretion of elastase was only detected using aortic cells. Tumour angiogenesis factor
(TAF), heparin or 12-0-tetradecanoyl-phorbol-acetate (TPA) had no effect on the levels of
cell-associated or secreted elastase.
Tissue cultured bovine capillary and aortic endothelial cells were examined for cellular and secreted proteinase activity. Cell-lysates from both sources showed significant elastase activity but differed in the level of activity and the pH-optimum and inhibition profile. Secretion of elastase was only detected using aortic cells. Tumour angiogenesis factor (TAF), heparin or 12-0-tetradecanoyl-phorbol-acetate (TPA) had no effect on the levels of cell-associated or secreted elastase.
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