[HTML][HTML] Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway
T Yamashita, M Konishi, A Miyake, K Inui… - Journal of Biological …, 2002 - ASBMB
The homeostasis of the plasma phosphate level is essential for many biological processes
including skeletal mineralization. The reabsorption of phosphate in the kidney is a major
determinant of the plasma levels of phosphate. Phosphatonin is a hormone-like factor that
specifically inhibits phosphate uptake in renal proximal epithelial cells. Recent studies on
tumor-induced osteomalacia suggested that phosphatonin was potentially identical to
fibroblast growth factor (FGF)-23. However, as purified recombinant FGF-23 could not inhibit …
including skeletal mineralization. The reabsorption of phosphate in the kidney is a major
determinant of the plasma levels of phosphate. Phosphatonin is a hormone-like factor that
specifically inhibits phosphate uptake in renal proximal epithelial cells. Recent studies on
tumor-induced osteomalacia suggested that phosphatonin was potentially identical to
fibroblast growth factor (FGF)-23. However, as purified recombinant FGF-23 could not inhibit …