Dendritic cells under the spell of prostaglandins
AE Morelli, AW Thomson - TRENDS in Immunology, 2003 - cell.com
AE Morelli, AW Thomson
TRENDS in Immunology, 2003•cell.comIn addition to their potential to modulate the maturation, interleukin-12 producing capacity
and Th-cell-polarizing ability of dendritic cells, there is new direct evidence that
prostaglandins (PGs) regulate chemokine receptor expression, cell migration and apoptosis
of these important professional antigen-presenting cells. We discuss these new insights in
relation to how PGs might influence innate and adaptive immune responses.
and Th-cell-polarizing ability of dendritic cells, there is new direct evidence that
prostaglandins (PGs) regulate chemokine receptor expression, cell migration and apoptosis
of these important professional antigen-presenting cells. We discuss these new insights in
relation to how PGs might influence innate and adaptive immune responses.
Abstract
In addition to their potential to modulate the maturation, interleukin-12 producing capacity and Th-cell-polarizing ability of dendritic cells, there is new direct evidence that prostaglandins (PGs) regulate chemokine receptor expression, cell migration and apoptosis of these important professional antigen-presenting cells. We discuss these new insights in relation to how PGs might influence innate and adaptive immune responses.
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