Increased interleukin-6 mRNA expression in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis
V Navikas, D Matusevicius, M Söderström… - Journal of …, 1996 - Elsevier
The increased intrathecal production of immunoglobulins within the cerebrospinal fluid
(CSF) compartment commonly observed in multiple sclerosis (MS) implicates participation of
B cell activating factors. One effect of the cytokine interleukin (IL)-6 is induction of
immunoglobulin production by activated B cells. Employing in situ hybridization (ISH) with
synthetic oligonucleotide probes, we measured numbers of IL-6 mRNA-expressing
mononuclear cells (MNC) in blood and CSF from patients with MS, aseptic meningo …
(CSF) compartment commonly observed in multiple sclerosis (MS) implicates participation of
B cell activating factors. One effect of the cytokine interleukin (IL)-6 is induction of
immunoglobulin production by activated B cells. Employing in situ hybridization (ISH) with
synthetic oligonucleotide probes, we measured numbers of IL-6 mRNA-expressing
mononuclear cells (MNC) in blood and CSF from patients with MS, aseptic meningo …