Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy
A Almasan, A Ashkenazi - Cytokine & growth factor reviews, 2003 - Elsevier
Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL)
is one of several members of the TNF gene superfamily that induce apoptosis through
engagement of death receptors. Apo2L/TRAIL is unusual as compared to any other cytokine
as it interacts with a complex system of receptors: two pro-apoptotic death receptors and
three anti-apoptotic decoys. This protein has generated tremendous excitement as a
potential tumor-specific cancer therapeutic because, as a stable soluble trimer, it selectively …
is one of several members of the TNF gene superfamily that induce apoptosis through
engagement of death receptors. Apo2L/TRAIL is unusual as compared to any other cytokine
as it interacts with a complex system of receptors: two pro-apoptotic death receptors and
three anti-apoptotic decoys. This protein has generated tremendous excitement as a
potential tumor-specific cancer therapeutic because, as a stable soluble trimer, it selectively …