TGF-beta as a T cell regulator in colitis and colon cancer
C Becker, MC Fantini, MF Neurath - Cytokine & growth factor reviews, 2006 - Elsevier
TGF-β is a pleiotropic cytokine with powerful immunosuppressive functions. Mice deficient
for TGF-β1 show a dramatic phenotype with severe multiorgan inflammation and die shortly
after birth. Recent investigations have highlighted the role of TGF-β in suppression of T cell
mediated autoimmune inflammation and anti-tumor immunity. In addition to its direct anti-
inflammatory effects on T cells, TGF-β has been implicated as central regulator of regulatory
T cells. TGF-β not only mediates the suppression of effector T cells by Tregs, recent …
for TGF-β1 show a dramatic phenotype with severe multiorgan inflammation and die shortly
after birth. Recent investigations have highlighted the role of TGF-β in suppression of T cell
mediated autoimmune inflammation and anti-tumor immunity. In addition to its direct anti-
inflammatory effects on T cells, TGF-β has been implicated as central regulator of regulatory
T cells. TGF-β not only mediates the suppression of effector T cells by Tregs, recent …